Cognitive problems among children exposed to antiepileptic drugs

Background

Antiepileptic drugs (AEDs) may have teratogenic effects. Growing evidence suggests reduced IQ in children after valproate exposure, and more pronounced neuro-psychiatric problems, including autism, have also been reported. Yet, knowledge on the long-term consequences of prenatal exposure to AEDs is scarce. 

Objectives

This Research Year project aims:

  • To estimate the long-term school performance in Danish children aged 9-15 years with prenatal exposure to AEDs enrolled in primary and lower secondary education. 

Perspectives

The study will help clarify to what extent prenatal exposure to AEDs may affect the cognitive abilities in children.
The study will focus on one of the areas that give rise to the greatest concerns among pregnant women with epilepsy.